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Figure 2 Composite End Point of Survival Free of Surgery for AR After Diagnosis of Asymptomatic AR

Patients are stratified according to QASE AR grading. The QASE-severe AR is defined as regurgitant volume 60 ml/beat or ERO 30 mm² (yellow line). The QASE-mild AR as regurgitant volume <30 ml/beat and ERO <10 mm² (brown line), and QASE-moderate AR (dotted orange line) as larger than mild (regurgitant volume 30 ml/beat or ERO 10 mm²), but not reaching QASE-severe criteria. The 5- and 10-year rates of the end point ± SE are indicated. Note the wide difference in outcome according to QASE grading at baseline. AVR = aortic valve replacement; other abbreviations as in Figure 1.