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Figure 1 Agreement Rates for Ischemia in Combined ADVANCE MPI 1 and 2

In 1,871 subjects, 3 blinded experts independently scored images on a 5-point scale using 17-segments and ischemia was categorized as 0 to 1 (no to minimal), 2 to 4 (small to moderate), or 5 (large). The overall average ischemia agreement rates between adenosine–adenosine and adenosine–regadenoson was 0.62 ± 0.03 and 0.63 ± 0.02 with an agreement difference of 0% (95% CI –6.2% to 6.8%), respectively. Regadenoson was noninferior to adenosine for detection of ischemia. ADVANCE MPI= ADenoscan Versus regAdenosoN Comparative Evaluation for Myocardial Perfusion Imaging; CI = confidence interval; SE = standard error.