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Figure 5 PET Imaging and Perfusion-Metabolism Mismatch in Hibernation

Positron emission tomography (PET) scan showing perfusion (top) to metabolism (bottom) mismatch in hibernating heart as an example of preserved cardiometabolic reserve. Rubidium-82 PETs in short-axis view (top row) show markedly decreased perfusion defects in the apical, inferior, inferolateral, and septal regions of the left ventricle at rest, which extends from distal to basal slices. [¹⁸F] 2-deoxy-2-fluoroglucose images acquired under glucose-loaded condition (lower row) show perfusion-metabolism mismatch pattern (the scintigraphic hallmark of hibernation) in all abnormally perfused myocardial regions at rest, with the exception of the anteroseptal region, which demonstrates matched perfusion-metabolism pattern (compatible with scarred myocardium). Reprinted, with permission, from Taegtmeyer and Dilsizian (64).