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Figure 1 Segmentation of the Aortic Wall and Color-Coded Signal Enhancement Before and After Targeted Fumagillin Treatment

(Top) Black blood image of the thoracic aorta (arrow) and segmentation of the vessel wall (outlined in yellow) is shown for the week 0 image. The color-coded overlay of signal enhancement (%) shows patchy areas of high angiogenesis. On the week 1 image, the signal enhancement has clearly decreased due to the antiangiogenic effect of targeted fumagillin treatment. (Bottom) The level of signal enhancement gradually increases at weeks 2 and 3 after fumagillin treatment, until week 4, when the level of enhancement is practically identical to the week 0 image.