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Figure 3 Cardiac Magnetic Resonance Signal Enhancement up to 8 Weeks After Treatment With Targeted Fumagillin Nanoparticles With and Without Oral Atorvastatin

(Top) Cardiac magnetic resonance enhancement in untreated (triangles), atorvastatin-treated (circles) and fumagillin-treated animals (squares) during 8 weeks of follow-up imaging. Untreated and statin-treated animals showed a constant level of angiogenesis in the aortic wall. Animals treated with targeted fumagillin nanoparticles at 0 and 4 weeks showed decreased angiogenesis (*p < 0.05) after each dose, which returned to baseline levels within 4 weeks. (Bottom) Enhancement in rabbits receiving atorvastatin alone (triangles) or in conjunction with 1 (squares) or 2 (circles) doses of targeted fumagillin nanoparticles. The combination of 2 fumagillin doses and statin produced a sustained decrease in angiogenesis (*p < 0.05).