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Figure 4 Liver Function Enzymes After 8 Weeks of Atorvastatin Treatment With or Without Targeted Fumagillin Nanoparticles

Blood samples drawn at the end of the 8-week study were assessed for liver function enzymes to assess the chronic effects of the high-lipid diet and experimental treatments. All values tended to be within normal ranges and identical for all treatment groups. Alkaline phosphate (AlkP), however, was elevated in all groups, and alanine aminotransferase (ALT) was increased in animals receiving 2 doses of targeted fumagillin nanoparticles and oral statin (Fum 2x + Statin) (*p < 0.05). AST = aspartate aminotransferase; Fum = fumagillin; GGT = gamma glutamyltransferase; NS = not significant.