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Figure 6 Sources of False Positive and False Negative

The graph displays medians (horizontal lines) and interquartile ranges (boxes) of block chemogram readings for different histologic classifications. (A) The LCP-negative class expanded into histologic subtypes. Higher y-axis values for LCP-negative result in false-positive readings. Fibroatheroma that were too small or thick-capped to be defined as LCP (FA) were the major source of false-positive readings. (B) The LCP-positive class expanded into histologic subtypes. Lower y-axis values for LCP-positive result in false-negative readings. The LCPs with calcified cores (Early FA-CC and Late FA-CC) were the main source of false-negative readings. AIT = adaptive intimal thickening; BF = bland fibrous plaque; CF = calcified fibrous plaque; CN = calcified nodule; -diff = spatially diffuse lipid; FA = fibroatheroma without calcified core; FA-CC = fibroatheroma with calcified necrotic core; IX = intimal xanthoma; NML = normal tissue; PIT = pathologic intimal thickening; -pool = spatially localized lipid pools; TCFA =thin-capped fibroatheroma; other abbreviations as in Figure 3.