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Figure 2 Patient OFDI-01 Longitudinal and Cross-Sectional Images of Left Anterior Descending Artery

(A) Longitudinal optical frequency domain imaging (OFDI) section, corresponding to the cut surface of (Fig. 1C). (B) Expanded view of dotted region in A, demonstrating a large calcific nodule (blue arrowheads) and a lipid pool with a thin fibrous cap (black arrow). (C) Expanded view of an OFDI cross-sectional image obtained at location of the black arrow in B and red arrowhead in Figure 1C, shows a lipid pool with a thin fibrous cap (black arrow) and a dense band of macrophages at the cap–lipid pool interface (green arrow). A thin flap of tissue (black arrowhead) can be seen over the cap. Scale bar in A, 5.0 mm. Scale bar in B, 1.0 mm. Tick marks in C, 0.25 mm. L = lipid pool.