This Article Figures Only Full Text Full Text (PDF) View CVN Interview Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JACC Imaging Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sharir, T. Articles by Berman, D. S. Search for Related Content PubMed Articles by Sharir, T. Articles by Berman, D. S.

High-Speed Myocardial Perfusion Imaging

Initial Clinical Comparison With Conventional Dual Detector Anger Camera Imaging

Tali Sharir, MD^_*,_*, Simona Ben-Haim, MD, DSc, Konstantine Merzon, MD^_*, Vitali Prochorov, MD^_*, Dalia Dickman, PhD, Shlomo Ben-Haim, MD, DSc, Daniel S. Berman, MD

^_* Procardia-Maccabi Healthcare Services, Tel-Aviv, Israel
UCL Institute of Nuclear Medicine, London, United Kingdom
Spectrum Dynamics, Caesarea, Israel
Cedars Sinai Medical Center, Los Angeles, California.

^_* Reprint requests and correspondence: Dr. Tali Sharir, Procardia, Maccabi Health Services, 156 Hayarkon St., Tel Aviv, Israel, 63451. (Email: tsharir{at}gmail.com).

Objectives: The purpose of this study was to compare myocardial perfusion imaging (MPI) with high-speed single-photon emission computed tomography (SPECT) with conventional SPECT imaging for the evaluation of myocardial perfusion in patients with known or suspected coronary artery disease.

Background: A novel technology has been developed for high-speed SPECT MPI by employing a bank of independently controlled detector columns with large-hole tungsten collimators and multiple cadmium zinc telluride crystal arrays.

Methods: A total of 44 patients (39 men) underwent same-day Tc-99m sestamibi stress/rest MPI. High-speed SPECT images were performed within 30 min after conventional SPECT. Stress and rest acquisition times were 16 and 12 min for conventional imaging and 4 and 2 min for high-speed SPECT, respectively. Myocardial counts/min (cpm) were calculated for both conventional SPECT and high-speed SPECT. Images were visually analyzed, and the summed stress score (SSS) and summed rest score (SRS) were calculated. Image quality and diagnostic confidence were qualitatively assessed.

Results: High-speed SPECT SSS and SRS correlated linearly with conventional SPECT respective scores (r = 0.93, p < 0.0001 for SSS, and r = 0.93, p < 0.0001 for SRS). Image quality was rated good and higher in 17 (94%) cases for high-speed SPECT and 16 (89%) cases for conventional SPECT. Of the 44 patients studied, 36 (81.8%) and 35 (79.5%) were diagnosed definitely normal or abnormal by conventional and high-speed SPECT, respectively (p = NS). Myocardial count rate was significantly higher in high-speed versus conventional SPECT (384 x 10^–3 ± 134 x 10^–3 cpm/min vs. 47 x 10^–3 ± 14 x 10^–3 cpm/min, respectively, p < 0.0001) for stress and (962 x 10^–3 ± 426 x 10^–3 cpm/min vs. 136 x 10^–3 ± 37 x 10^–3 cpm/min, respectively, p < 0.001) for rest.

Conclusions: High-speed SPECT provides fast MPI with high image quality and up to 8 times increased system sensitivity. The amount of perfusion abnormality visualized by high-speed SPECT is highly correlated to conventional SPECT, with an equivalent level of diagnostic confidence.

Abbreviations and Acronyms   CAD = coronary artery disease   CZT = cadmium zinc telluride   LAD = left anterior descending coronary artery   MLEM = maximum likelihood expectation maximization method   RCA = right coronary artery   ROI = region of interest   SPECT = single-photon emission computed tomography   SRS = summed rest score   SSS = summed stress score   2D = 2-dimensional

Related articles in JACC Imaging:

High-Speed Myocardial Perfusion Imaging: Dawn of a New Era in Nuclear Cardiology?

Robert O. Bonow
JACC Imaging 2008 1: 164-166. [Full Text]  

This article has been cited by other articles:

				R. O. Bonow High-Speed Myocardial Perfusion Imaging: Dawn of a New Era in Nuclear Cardiology? J. Am. Coll. Cardiol. Img., March 1, 2008; 1(2): 164 - 166. [Full Text] [PDF]