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Myocardial Strain Measurement With 2-Dimensional Speckle-Tracking Echocardiography

Definition of Normal Range

Thomas H. Marwick, MD^_*,_*, Rodel L. Leano, BS^_*, Joseph Brown, BS^_*, Jing-Ping Sun, MD, Rainer Hoffmann, MD, Peter Lysyansky, PhD, Michael Becker, MD, James D. Thomas, MD

^_* University of Queensland, Brisbane, Australia
Cleveland Clinic, Cleveland, Ohio
RWTH Hospital, Aachen, Germany
General Electric Medical Systems, Haifa, Israel

^_* Reprint requests and correspondence: Dr. Thomas H. Marwick, University of Queensland, Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia (Email: t.marwick{at}uq.edu.au).

The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of –18.6 ± 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.

Key Words: regional left ventricular function • strain • speckle tracking

Abbreviations and Acronyms   2DS = 2-dimensional strain   ANOVA = analysis of variance   LV = left ventricle/ventricular   SR = strain rate   STE = speckle-tracking echocardiography   TQ = tracking quality

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