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Outcomes Research in Cardiovascular Imaging

Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute

Pamela S. Douglas, MD^_*,_*, Allen Taylor, MD, Diane Bild, MD, Robert Bonow, MD^||, Philip Greenland, MD^||, Michael Lauer, MD, Frank Peacock, MD^¶, James Udelson, MD^#

^_* Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina
Department of Medicine, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC
Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
^|| Northwestern University Feinberg School of Medicine, Chicago, Illinois
^¶ Emergency Medicine, Cleveland Clinic, Cleveland, Ohio
^# Division of Cardiology, Tufts Medical Center, Boston, Massachusetts

^_* Reprint requests and correspondence: Dr. Pamela S. Douglas, 7022 North Pavilion DUMC, P.O. Box 17969, Durham, North Carolina 27715 (Email: pamela.douglas{at}duke.edu).

In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imaging in: 1) screening the asymptomatic patient for coronary artery disease; 2) assessment of patients with stable angina; 3) identification of acute coronary syndromes in the emergency room; and 4) assessment of heart failure patients with chronic coronary artery disease with reduced left ventricular ejection fraction. This study highlights several possible trial designs for each clinical situation.

Key Words: cardiovascular imaging • chest pain diagnosis • clinical trials

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