High-Speed Myocardial Perfusion ImagingInitial Clinical Comparison With Conventional Dual Detector Anger Camera Imaging
Tali Sharir, MD*,*,
Simona Ben-Haim, MD, DSc ,
Konstantine Merzon, MD*,
Vitali Prochorov, MD*,
Dalia Dickman, PhD ,
Shlomo Ben-Haim, MD, DSc,
Daniel S. Berman, MD
* Procardia-Maccabi Healthcare Services, Tel-Aviv, Israel
UCL Institute of Nuclear Medicine, London, United Kingdom
Spectrum Dynamics, Caesarea, Israel
Cedars Sinai Medical Center, Los Angeles, California.
View larger version (35K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 Detector Configuration and ROI-Centric Scanning
The system uses 9 collimated, pixilated cadmium zinc telluride detector columns, mounted vertically in 90° geometry. Data are acquired by the detector columns rotating in synchrony, focusing on the region of interest (ROI) (the heart).
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 Correlation of Stress Perfusion Abnormality
The correlation between the summed stress score (SSS) by high-speed single-photon emission computed tomography (SPECT) versus conventional SPECT was highly linear (A). The Bland-Altman plot demonstrates that all points except for 2 are within the mean difference (1.09) ± 2 standard deviations (B).
|
|
View larger version (13K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Correlation of Resting Perfusion Abnormality
The correlation between the summed rest score (SRS) by high-speed single-photon emission computed tomography (SPECT) versus conventional SPECT was excellent (A). Bland-Altman plot demonstrates that all points except for 2 are within the mean difference (0.89) ± 2 standard deviations (B).
|
|
View larger version (61K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 MPI by Conventional and High-Speed SPECT in a Patient With Low Pre-Scan Likelihood
Images of conventional single-photon emission computed tomography (SPECT) (top panel) and high-speed SPECT (bottom panel) showing normal myocardial perfusion in a 67-year-old man, with a history of hypertension, non-anginal chest pain, and inconclusive stress test.
|
|
View larger version (10K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 5 System Sensitivity
The higher system sensitivity is demonstrated by significantly higher myocardial count rate (7 to 8 times) compared with conventional single-photon emission tomography (SPECT) at stress and rest images. CPM = counts/min.
|
|
View larger version (13K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 6 Diagnostic Confidence
Equal diagnostic confidence by high-speed single-photon emission computed tomography (SPECT) compared with conventional SPECT is shown by similar number of patients within definitely normal and abnormal scan categories and similar number of borderline or equivocal scans. EQ = equivocal; PA = probably abnormal; PN = probably normal.
|
|
View larger version (64K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 7 MPI by Conventional and High-Speed SPECT in a Patient With Previous Myocardial Infarction
Conventional single-photon emission computed tomography (SPECT) (top panel) and high-speed SPECT (bottom panel) images showing infarct and ischemia of the left anterior descending coronary artery and ischemia of the right coronary artery (see text).
|
|
|
