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Impact of Mitral Annular Calcification on Cardiovascular Events in a Multiethnic Community

The Northern Manhattan Study

Shun Kohsaka, MD^_*, Zhezhen Jin, PhD, Tatjana Rundek, MD, PhD, Bernadette Boden-Albala, PhD, Shunichi Homma, MD, FACC^_*, Ralph L. Sacco, MD, MS^||, Marco R. Di Tullio, MD^_*,_*

^_* Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York
Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York
^|| Department of Neurology, Epidemiology, and Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Event-Free Probability Curve for MI, VD, and IS Event-free probability curve for myocardial infarction (MI) (A), vascular death (VD) (B), and ischemic stroke (IS) (C) based on presence of mitral annular calcification (MAC), which demonstrated a significant increase in each of these vascular outcomes related to its thickness. The incidence of MI, VD, and IS was 13.8, 20.3, and 10.7/1,000 person-years, respectively, in subjects with MAC, and 4.7, 7.5, and 6.1/1,000 person-years, respectively, in subjects without MAC.