Thoracic Aortic Calcium Versus Coronary Artery Calcium for the Prediction of Coronary Heart Disease and Cardiovascular Disease Events
Nathan D. Wong, PhD, MPH, FACC*,
Heidi Gransar, MS ,
Leslee Shaw, PhD ,
Donna Polk, MD, MPH, FACC,
Johanna H. Moon, MPH,
Romalisa Miranda-Peats, MPH,
Sean W. Hayes, MD, FACC,
Louise E.J. Thomson, MBChB,
Alan Rozanski, MD, FACC ,
John D. Friedman, MD, FACC,
Daniel S. Berman, MD, FACC,*
* Division of Cardiology, University of California, Irvine, California
Departments of Imaging and Medicine and Burns & Allen Research Institute, Cedars-Sinai Medical Center, and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California
Emory University School of Medicine, Atlanta, Georgia
Department of Cardiology, St. Luke's Roosevelt Hospital Center, New York, New York
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Figure 1 Example of Scan Showing Calcification in the AAO and DAO, and LAD and RCA
Example of scan showing calcifications (arrows) in the ascending thoracic aorta (AAO) and descending thoracic aorta (DAO), the aortic valve (AV), left anterior descending artery (LAD), and right coronary artery (RCA). Note that the AV calcification was not included in the aortic scoring.
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Figure 2 Distribution of TAC According to Category of CAC
Values indicate the percentage of participants in each thoracic aortic calcium (TAC) score category (0, 1 to 9, 10 to 99, 100 to 399, and  400) with indicated coronary artery calcium (CAC) scores (0, 1 to 9, 10 to 99, 100 to 399, and 400). p < 0.001 comparing distribution of TAC groups across CAC groups.
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Figure 3 ROC Curve Analysis for CAC and TAC in Predicting Hard CHD Events
Area under the receiver-operator characteristic (ROC) curve is provided in parentheses. The p values for contrasts: addition of CAC over FRS alone, p = 0.10; further addition of TAC, p = 0.67; addition of TAC over FRS alone, p = 0.70. CHD = coronary heart disease; FRS = Framingham Risk Score; other abbreviations as in Figure 2.
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Figure 4 ROC Curve Analysis for CAC and TAC in Predicting Total CHD Events
Area under the ROC curve is provided in parentheses. The p values for contrasts: addition of CAC over FRS alone, p = 0.004; further addition of TAC, p = 0.92; addition of TAC over FRS alone, p = 0.28. Abbreviations as in Figures 2 and 3.
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Figure 5 ROC Curve Analysis for CAC and TAC Separately in Predicting Total CVD Events
Area under the ROC curve is provided in parentheses. The p values for contrasts: addition of CAC over FRS alone, p = 0.006; further addition of TAC, p = 0.99; addition of TAC over FRS alone, p = 0.43. CVD = cardiovascular disease; other abbreviations as in Figures 2 and 3.
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