Accuracy of Optical Coherence Tomography in the Evaluation of Neointimal Coverage After Stent Implantation
Akira Murata, MD*,
David Wallace-Bradley, BS*,
Armando Tellez, MD*,
Carlos Alviar, MD*,
Michael Aboodi, BS*,
Alexander Sheehy, MS ,
Leslie Coleman, DVM, MS,
Laura Perkins, DVM, PhD,
Gaku Nakazawa, MD ,
Gary Mintz, MD*,
Greg L. Kaluza, MD, PhD*,
Renu Virmani, MD,
Juan F. Granada, MD*,*
* Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, New York
Abbott Vascular, Santa Clara, California
CV Path, Gaithersburg, Maryland
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Figure 1 Distribution of Neointimal Thickness Among 6,640 Individual Stent Struts Assessed by OCT (2,676 Struts) and Histology (3,964 Struts)
Both OCT and histology detected similar proportions of uncovered struts, different proportions of struts with 20 to 80 µm of coverage, and similar proportions with 80 to 100 µm of coverage. OCT = optical coherence tomography.
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Figure 2 OCT Frame
Histological slide correlation analysis combining all 4 stents groups and showing good correlation for lumen area, neointimal area, and neointimal thickness, but poor correlation for stent area. OCT = optical coherence tomography.
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Figure 3 Representative Examples of OCT and Histology Correlation
Examples of intraobserver (Observer 1) (A and B) and interobserver (Observer 2) (C) correlation in stent and lumen measurements as assessed in vivo by OCT. Corresponding hematoxylin and eosin–stained histological cross section showing accurate coregistration of OCT frames with excised tissue (D). OCT = optical coherence tomography.
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