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Figure 6 SPECT Scans for RGD-Based Targeting of Neoangiogenesis
On the left are shown reconstructed short-axis (SA), vertical (VLA), and horizontal long-axis (HLA) single-photon computed tomography (SPECT) slices from the thallium scans (top rows) and I-123 scans (bottom rows) from 1 representative animal treated with vascular endothelial growth factor (VEGF) and 1 animal treated with saline. The VEGF-injected animal shows a mild anterolateral thallium defect and focal uptake of [123I]Gluco-RGD into the anterolateral wall. The colocalization of the thallium defect and focal hotspot is better displayed on the polar maps. The saline-injected animal shows a mild-to-moderate anterolateral and apical defect without focal uptake of of [123I]Gluco-RGD in the heart. RGD = arginine-glycine-aspartic acid.
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