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Figure 2 Aortic Signal Enhancement up to 4 Weeks After Treatment With Targeted Fumagillin Nanoparticles
(Top) Serial imaging of angiogenesis in untreated (triangles) and fumagillin-treated animals remaining on high-cholesterol diet (squares) or switched to normal chow (circles). Fumagillin treatment at week 0 reduced angiogenesis compared with untreated control animals (*p < 0.05), but withdrawing the high-cholesterol feed had no effect. (Bottom) Aortic angiogenesis in rabbits without treatment (triangles), with 30 µg/kg fumagillin (circles), or with 90 µg/kg fumagillin (squares). Fumagillin treatment at 30 versus 90 µg/kg produced identical responses. *p < 0.05.
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