Table 6

JACC: Cardiovascular Imaging

Volume 10, Issue 12, December 2017 DOI: 10.1016/j.jcmg.2017.11.001

Noninvasive Cardiac Imaging and the Prediction of Heart Failure Progression in Preclinical Stage A/B Subjects

Fei Fei Gong, Duncan J. Campbell and David L. Prior

Prediction of Symptomatic HF According to Any of a Composite of Imaging Parameters for LVD

First Author (Ref. #)	Study/Country	Study Population	Age (yrs)	Follow-Up (Mean Years)	Imaging	Definition of LVD	Definition of HF	N	Cases	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Yang et al. (44)	Australia	Stage A/B HF^∗	≥65	1.2	TTE	LVM (>95 g/m² in women, >115 g/m² in men) OR GLS >–18 OR E/e′ >13 OR LA enlargement (LAVI >34 ml/m²)	Physician	410	51	82	41	17	94
Shah et al. (43)	ARIC/U.S.	Stage A/B HF	67–91	1.7 (median)	TTE	Structural, systolic, or diastolic abnormality†	Death/HF hospitalization	4,693	149	72	48	4	98

ARIC = Atherosclerosis Risk in Communities; LA = left atrial; LVD = left ventricular dysfunction; other abbreviations as in Tables 2 and 3.

↵∗ Patients with known coronary disease, >moderate valve disease, LVEF <40%, or atrial fibrillation were excluded.
↵† Structural abnormality defined as per Table 2.