Author + information
- Received August 1, 2017
- Revision received September 27, 2017
- Accepted October 18, 2017
- Published online March 5, 2018.
- Matthew S. Chin, MDa,
- Michael Steigner, MDb,
- Wenqing Yin, MD, PhDc,
- Raymond Y. Kwong, MD, MPHc and
- Andrew M. Siedlecki, MDc,∗ ()
- aDepartment of Radiology, Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania
- bDepartment of Radiology, Brigham and Women’s Hospital, Boston, Massachusetts
- cDepartment of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
- ↵∗Address for correspondence:
Dr. Andrew M. Siedlecki, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, HIM Rm 568B, Boston, Massachusetts 02115.
Diagnostic angiography is sometimes inevitable in patients with estimated glomerular filtration rate (eGFR) of <30 ml/min/1.73 m2 who are not yet on dialysis. However, iodine- or gadolinium-based contrast agents pose a risk of acute kidney injury or nephrogenic systemic fibrosis, respectively (1). Ferumoxytol-enhanced cardiac magnetic resonance angiography (cMRA) (Figure 1) can be an alternative but anaphylactic reactions have been described. We present a brief pictorial overview of our experience of its use in 5 patients (Figures 2, 3, 4, and 5⇓⇓⇓⇓, Online Videos) for assessing the coronary artery tree without complications.
In summary, we built on previous work that depicted the resolution of ferumoxytol-enhanced cMRA in visualizing the right coronary artery. We demonstrated that the left coronary artery tree in adults could also be visualized (Figure 6) and corresponded with findings of conventional coronary angiography, including segmental stenosis.
Ferumoxytol for Magnetic Resonance Imaging in Patients With Severe Kidney Disease NCT02954510. Dr. Siedlecki is funded by grant K08DK089002 from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases and by research grant #2016D004506 from AMAG Pharmaceuticals, Inc. All authors have reported that they have no relationships relevant to the contents of this paper to disclose. Zahi Fayad, MD, served as the Guest Editor for this paper.
- Received August 1, 2017.
- Revision received September 27, 2017.
- Accepted October 18, 2017.
- 2018 American College of Cardiology Foundation