Author + information
- Received December 26, 2017
- Revision received April 12, 2018
- Accepted April 13, 2018
- Published online August 6, 2018.
- Milind Y. Desai, MDa,∗∗ (, )#JACCCVIMG#radiationheartdisease,
- Christine L. Jellis, MD, PhDa,∗,
- Rupesh Kotecha, MDb,
- Douglas R. Johnston, MDa and
- Brian P. Griffin, MDa
- aHeart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
- bDepartment of Radiation Oncology, Cancer Institute, Cleveland Clinic, Cleveland, Ohio
- ↵∗Address for correspondence:
Dr. Milind Y. Desai, Department of Cardiovascular Medicine, Desk J1-5, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195.
Radiation-associated cardiac disease (RACD) results in complex clinical presentations, unique management issues, and increased morbidity and mortality. Patients typically present years or even decades after radiation exposure, with delayed-onset cardiac damage sustained from high cumulative doses. Multimodality imaging is crucial to determine the manifestations and severity of disease because symptoms are often nonspecific. Comprehensive screening using a coordinated approach may enable early detection. However, timing of intervention should be carefully considered in these patients because surgery is often complex and high-risk second surgeries should be minimized in the long-term. This review aims to provide treating physicians with a comprehensive and clinically focused overview of RACD, including clinical/imaging manifestations, multi-modality screening recommendations, and management options.
↵∗ Drs. Desai and Jellis contributed equally to this work and are joint first authors.
Dr. Desai acknowledges the Haslam Family Endowed Chair in Cardiovascular Medicine and the Khouri Family philanthropic gift for Research in Early Detection of Coronary Artery Disease. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received December 26, 2017.
- Revision received April 12, 2018.
- Accepted April 13, 2018.
- 2018 American College of Cardiology Foundation
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