Author + information
- Received July 11, 2018
- Revision received October 10, 2018
- Accepted October 18, 2018
- Published online January 7, 2019.
- Mhairi K. Doris, MDa,
- Russell J. Everett, MDa,
- Matthew Shun-Shin, MDb,
- Marie-Annick Clavel, DVM, PhDc and
- Marc R. Dweck, MD, PhDa,∗ ()
- aBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, United Kingdom
- bNational Heart and Lung Institute, Imperial College London, London, United Kingdom
- cDepartment of Medicine, Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada
- ↵∗Address for correspondence:
Dr. Marc R. Dweck, British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 49 Little France Crescent, Edinburgh, Scotland EH16 4SB, United Kingdom.
Aortic stenosis represents a growing health care burden in high-income countries. Currently, the only definitive treatment is surgical or transcatheter valve intervention at the end stages of disease. As the understanding of the underlying pathophysiology evolves, many promising therapies are being investigated. These seek to both slow disease progression in the valve and delay the transition from hypertrophy to heart failure in the myocardium, with the ultimate aim of avoiding the need for valve replacement in the elderly patients afflicted by this condition. Noninvasive imaging has played a pivotal role in enhancing our understanding of the complex pathophysiology underlying aortic stenosis, as well as disease progression in both the valve and myocardium. In this review, the authors discuss the means by which contemporary imaging may be used to assess disease progression and how these approaches may be utilized, both in clinical practice and research trials exploring the clinical efficacy of novel therapies.
Dr. Doris is supported by the BHF (FS/17/19/33226). Dr. Dweck is supported by the BHF (FS/14/78/31020) and is the recipient of the Sir Jules Thorn Award for Biomedical Research 2015 (15/JTA). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received July 11, 2018.
- Revision received October 10, 2018.
- Accepted October 18, 2018.
- 2019 The Authors