Author + information
- Received December 6, 2017
- Revision received February 7, 2018
- Accepted February 8, 2018
- Published online May 6, 2019.
- Ana Martinez-Naharro, MDa,∗,
- Tushar Kotecha, MBChBa,b,∗,
- Karl Norrington, MBBSa,
- Michele Boldrini, MDa,
- Tamer Rezk, MBBSa,
- Candida Quarta, MD, PhDa,
- Thomas A. Treibel, PhDb,c,
- Carol J. Whelan, MDa,
- Daniel S. Knight, MDa,
- Peter Kellman, PhDd,
- Frederick L. Ruberg, MDe,
- Julian D. Gillmore, MD, PhDa,
- James C. Moon, MDb,c,
- Philip N. Hawkins, PhDa and
- Marianna Fontana, MD, PhDa,∗ ()
- aNational Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London, United Kingdom
- bInstitute of Cardiovascular Science, University College London, London, United Kingdom
- cBarts Heart Centre, West Smithfield, London, United Kingdom
- dNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- eAmyloidosis Center and Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts
- ↵∗Address for correspondence:
Dr. Marianna Fontana, National Amyloidosis Centre, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, United Kingdom.
Objectives This study evaluated the prognostic potential of native myocardial T1 in cardiac transthyretin amyloidosis (ATTR) and compared native T1 with extracellular volume (ECV) in terms of diagnostic accuracy and prognosis.
Background ATTR is an increasingly recognized cause of heart failure that has an overlapping clinical phenotype with hypertrophic cardiomyopathy (HCM). Native T1 mapping by cardiac magnetic resonance (CMR) is useful for diagnosis in cardiac amyloidosis but its prognostic potential has never been assessed.
Methods A total of 134 patients with wild-type ATTR (ATTRwt) (122 men; age 76 ± 7 years), 81 patients with hereditary-type ATTR (ATTRm) (60 men; age 69 ± 11 years), 44 patients with HCM (32 men; age 51 ± 13 years), and 12 asymptomatic mutation carriers (4 men; age 47 ± 10 years) were studied. All subjects underwent CMR with T1 mapping and ECV measurement. ATTR patients also underwent 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) scintigraphy.
Results Native T1 and ECV were elevated in ATTR compared with HCM (p < 0.001) and were both associated with a high diagnostic accuracy (area under the curve [AUC]: 0.87; 95% confidence interval [CI]: 0.82 to 0.91) for T1 and an AUC of 0.91 (95% CI: 0.87 to 0.94) for ECV. No significant difference in native T1 and ECV was found between ATTRwt and ATTRm, and ECV correlated well with 99mTc-DPD scintigraphy. During follow-up of a mean of 32 ± 17 months, 55 ATTRwt and 40 ATTRm patients died. Native T1 and ECV predicted death (T1: hazard ratio [HR]: 1.225 for each 59-ms increase; 95% CI: 1.010 to 1.486; p < 0.05; ECV: HR: 1.155 for each 3% increase; 95% CI: 1.097 to 1.216; p < 0.001), but only ECV remained independently predictive after adjustment for age, N-terminal pro−B-type natriuretic peptide, left ventricular ejection fraction, E/E′, left ventricular mass index, DPD grade, and late gadolinium enhancement.
Conclusions Native T1 mapping and ECV are good diagnostic techniques for cardiac ATTR that are associated with prognosis. Both parameters correlated with mortality, but only ECV remained independently predictive of prognosis, suggesting that it is a more robust marker in cardiac ATTR.
↵∗ Drs. Martinez-Naharro and Kotecha contributed equally to this work and are joint first authors.
Dr. Norrington is deceased. Dr. Moon has received an unrestricted research grant from GlaxoSmithKline and has also been paid a consultancy fee for trial design. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received December 6, 2017.
- Revision received February 7, 2018.
- Accepted February 8, 2018.
- 2019 American College of Cardiology Foundation
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