Intravascular Polarimetry in Patients With Coronary Artery Disease
Kenichiro Otsuka, Martin Villiger, Antonios Karanasos, Laurens J.C. van Zandvoort, Pallavi Doradla, Jian Ren, Norman Lippok, Joost Daemen, Roberto Diletti, Robert-Jan van Geuns, Felix Zijlstra, Gijs van Soest, Jouke Dijkstra, Seemantini K. Nadkarni, Evelyn Regar and Brett E. Bouma
Polarization Properties in Plaque Progression and Destabilization
In a less advanced stage of atherogenesis, birefringence and depolarization increase along with the proliferation of thick collagen, smooth muscle cells, and lipid content (atherogenesis and progression). Birefringence of the plaques declines in hand with the reduction of interstitial collagen, and the development of the lipid/necrotic core, which in turn leads to a significant increase in depolarization, corresponding to the transition of pathological intimal thickening (fibrous plaque [FP] and fibrofatty plaque [FF]) to a fibroatheroma (progression and destabilization). ACS = acute coronary syndrome; FC = fibrocalcified plaque; PR = plaque rupture; TCFA = thin-cap fibroatheroma; ThCFA = thick-cap fibroatheroma.