Author + information
- Received September 17, 2007
- Revision received December 10, 2007
- Accepted December 14, 2007
- Published online January 1, 2009.
- Thomas H. Marwick, MD⁎,⁎ (, )
- Rodel L. Leano, BS⁎,
- Joseph Brown, BS⁎,
- Jing-Ping Sun, MD†,
- Rainer Hoffmann, MD‡,
- Peter Lysyansky, PhD§,
- Michael Becker, MD‡ and
- James D. Thomas, MD†
Reprint requests and correspondence:
Dr. Thomas H. Marwick, University of Queensland, Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia
The interpretation of wall motion is an important component of echocardiography but remains a source of variation between observers. It has been believed that automated quantification of left ventricular (LV) systolic function by measurement of LV systolic strain from speckle-tracking echocardiography might be helpful. This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of −18.6 ± 0.1%. Although strain was influenced by weight, blood pressure, and heart rate, these features accounted for only 16% of variance. However, there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
Dr. Lysyansky is an employee of General Electric Medical Systems. Drs. Marwick, Thomas, and Hoffmann have received research support from General Electric Medical Systems, Horten, Norway. This study was supported in part by General Electric Medical Systems and in part by a grant from the Princess Alexandra Hospital Foundation, Brisbane, Australia. Anthony N. DeMaria, MD, MACC, served as Guest Editor for this paper
- Received September 17, 2007.
- Revision received December 10, 2007.
- Accepted December 14, 2007.
- American College of Cardiology Foundation