Author + information
- Received May 7, 2009
- Revision received July 29, 2009
- Accepted August 10, 2009
- Published online December 1, 2009.
- Bethany A. Austin, MD⁎,
- W.H. Wilson Tang, MD⁎,
- E. Rene Rodriguez, MD†,
- Carmela Tan, MD†,
- Scott D. Flamm, MD⁎‡,
- David O. Taylor, MD⁎,
- Randall C. Starling, MD, MPH⁎ and
- Milind Y. Desai, MD⁎‡⁎ ()
Reprint requests and correspondence:
Dr. Milind Y. Desai, Director, Cardiac CT and MR, Department of Cardiovascular Medicine, J1-5, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195
Objectives We sought to assess the diagnostic accuracy and incremental prognostic value of delayed hyper-enhancement cardiac magnetic resonance (DHE-CMR) compared with electrocardiographic and transthoracic echocardiographic (TTE) parameters in such patients.
Background Utility of DHE-CMR in the diagnosis of patients with suspected cardiac amyloidosis (CA) has recently been demonstrated, but its incremental prognostic utility is unclear.
Methods Forty-seven consecutive patients (mean age 63 years, 70% men, 55% New York Heart Association functional class >II) with suspected CA who underwent electrocardiography (ECG), TTE, DHE-CMR, and biopsy (38 endomyocardial, 9 extracardiac) were studied. Low voltage on ECG was defined as S-wave in lead V1 + R-wave in lead V5 or V6 <15 mm. TTE parameters, including deceleration time, E/E′ ratio, and diastolic grade were recorded. CMR was considered positive with diffuse DHE of the subendocardium extending to adjacent myocardium. All-cause mortality was ascertained.
Results In the study population, 59% had low voltage on ECG, 30% had abnormal deceleration time ≤150 ms, 38% had E/E′ ratio >15, and 47% had advanced (pseudonormal or restrictive) diastology. The diagnostic accuracy of DHE-CMR in patients undergoing endomyocardial biopsy was as follows: sensitivity 88%, specificity 90%, positive predictive value 88%, and negative predictive value 90%. On multivariable logistic regression testing of the diagnostic ability of various noninvasive imaging parameters, only DHE-CMR was significant (Wald chi-square statistic 9.6, p < 0.01). At 1-year post-biopsy, there were 9 (19%) deaths. On Cox proportional hazards analysis, only positive DHE-CMR was a predictor of 1-year mortality (Wald chi-square statistic 4.91, p = 0.03).
Conclusions A characteristic DHE-CMR pattern is more accurate for diagnosis and is a stronger predictor of 1-year mortality in patients with suspected CA as compared with other noninvasive parameters.
The institution receives modest research support from Siemens Medical Solutions.
- Received May 7, 2009.
- Revision received July 29, 2009.
- Accepted August 10, 2009.
- American College of Cardiology Foundation