Author + information
- Received November 18, 2008
- Revision received December 30, 2008
- Accepted January 9, 2009
- Published online April 1, 2009.
- Theodore Abraham, MD⁎,
- David Kass, MD⁎,
- Giovanni Tonti, MD†,
- Gery F. Tomassoni, MD‡,
- William T. Abraham, MD§,
- Jeroen J. Bax, MD∥ and
- Thomas H. Marwick, MBBS, PhD¶,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Thomas H. Marwick, University of Queensland School of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Qld 4102, Australia
Although a prognostic benefit has been shown from cardiac resynchronization therapy, questions are often directed toward the prediction of symptomatic or functional benefit. Recent multicenter trials have shown the pitfalls of current mechanical markers of left ventricular synchrony, but these negative trial results have not marked the conclusion of efforts to predict outcome. Potential new contributors to the assessment of mechanical synchrony include echocardiographic and magnetic resonance techniques for the assessment of myocardial deformation. Nonsynchrony markers that seem promising include assessment of the location and extent of myocardial scar and imaging of the coronary venous and phrenic nerve anatomy.
Drs. Abraham and Kass are consultants and receive research support from Boston Scientific. Dr. Tonti has received research grants from Siemens. Dr. Tomassoni received honoraria or is a consultant for Siemens and Biosense Webster. Dr. Bax has received research grants from GE Healthcare, BMS Medical Imaging, Edwards Lifescience, St. Jude, Boston Scientific, Medtronic, and Biotronik. Dr. Marwick has received research grant support from GE Medical Systems, Philips, and Siemens. Supported in part by a Program grant (519823) from the National Health and Medical Research Council, Canberra, Australia.
Section Editor: Mani A. Vannan, MBBS
- Received November 18, 2008.
- Revision received December 30, 2008.
- Accepted January 9, 2009.
- American College of Cardiology Foundation
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