Author + information
- Received October 30, 2008
- Revision received January 29, 2009
- Accepted February 2, 2009
- Published online April 1, 2009.
- Feng Xie, MD⁎,
- John Lof, MS⁎,
- Carr Everbach, PhD†,
- Anming He, PhD‡,
- Richard M. Bennett, PhD‡,
- Terry Matsunaga, PhD§,
- Jason Johanning, MD⁎ and
- Thomas R. Porter, MD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Thomas R. Porter, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, Nebraska 68198-2265
The purpose of this study was to determine whether high mechanical index (MI) impulses from diagnostic ultrasound (DUS) could dissolve intravascular thrombi using intravenous microbubbles. Using a canine model, DUS was applied during a continuous intravenous infusion of microbubbles. Completely thrombosed grafts were assigned to 2 treatment regimens: low-MI (<0.5-MI) ultrasound alone; or intermittent high-MI impulses (1.9-MI) guided by low-MI ultrasound (contrast pulse sequencing). A 20-MHz cavitation detector was placed confocal to the ultrasound transducer to make intravascular cavitation measurements in 1 dog. Intravascular cavitational activity was detected when an MI of >0.5 was applied. In grafts treated with intermittent high-MI ultrasound, angiographic success was 71% at 30 min and 79% at 45 min, compared with 20% and 30% at these times in the low-MI ultrasound alone group (p < 0.05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion.
Supported in part by ImaRx Therapeutics, Inc., Tucson, Arizona, and Siemens Medical Solutions, Mountain View, California.
Section Editor: Amir Lerman, MD
- Received October 30, 2008.
- Revision received January 29, 2009.
- Accepted February 2, 2009.
- American College of Cardiology Foundation