Author + information
Address for correspondence:
Dr. Richard H. Marcus, Iowa Heart Center, 5880 University Avenue, West Des Moines, Iowa 50266
cardiac resynchronization therapy (crt) has been targeted primarily at improving left ventricular systolic function. Whereas the discordance rate between the reported symptomatic response to CRT and parameters of systolic function has consistently been high, there is excellent concordance between the symptomatic response to pacemaker therapy and objective measures of diastolic function.
Pacemaker therapy targeted primarily at parameters of diastolic function may have a much greater role to play in the management of heart failure than has been recognized previously. The degree to which altered ventricular loading conditions induced by improvements in diastolic function might contribute to the long-term benefits of CRT, such as reverse remodeling, has yet to be defined.
- American College of Cardiology Foundation