Coronary Function Versus Stenosis and Clinical Outcomes
(A) Randomized trial of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) compared to arteriographically guided PCI in 1,008 patients. Reproduced, with permission, from Tonino et al. (18). The FFR-guided group had fewer invasive procedures and a significantly lower composite end point of death, nonfatal myocardial infarction, and repeat revascularization at 1 year (p = 0.02). (B) Randomized trial of PCI compared with medical treatment in 2,287 patients with coronary stenosis that was suitable for PCI by arteriogram, showing no mortality advantage of PCI over medical treatment. Reproduced, with permission, from Boden et al. (22).