Author + information
- Received May 20, 2010
- Revision received August 6, 2010
- Accepted August 23, 2010
- Published online November 1, 2010.
- Shashank Sathyanarayana, PhD⁎,
- Michael Schär, PhD⁎,†,
- Dara L. Kraitchman, VMD, PhD⁎ and
- Paul A. Bottomley, PhD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Paul A. Bottomley, Division of MR Research, Department of Radiology, Johns Hopkins University, Park Building 310, 600 North Wolfe Street, Baltimore, Maryland 21287
Fast, minimally invasive, high-resolution intravascular imaging is essential for identifying vascular pathological features and for developing novel diagnostic tools and treatments. Intravascular magnetic resonance imaging (MRI) with active internal probes offers high sensitivity to pathological features without ionizing radiation or the limited luminal views of conventional X-rays, but has been unable to provide a high-speed, high-resolution, endoscopic view. Herein, real-time MRI endoscopy is introduced for performing MRI from a viewpoint intrinsically locked to a miniature active, internal transmitter–receiver in a clinical 3.0-T MRI scanner. Real-time MRI endoscopy at up to 2 frames/s depicts vascular wall morphological features, atherosclerosis, and calcification at 80 to 300 μm resolution during probe advancement through diseased human iliac artery specimens and atherosclerotic rabbit aortas in vivo. MRI endoscopy offers the potential for fast, minimally invasive, transluminal, high-resolution imaging of vascular disease on a common clinical platform suitable for evaluating and targeting atherosclerosis in both experimental and clinical settings.
Drs. Sathyanarayana and Schär are currently full-time employees of GE Healthcare, Bangalore, India, and Philips Healthcare, respectively. Dr. Sathyanarayana was a graduate student trainee and not a GE employee at the time of the work. Dr. Schär is a Visiting Scientist at Johns Hopkins University. This work was supported by National Institutes of Health grants R01 EB007829 and R01 HL090728 (to Dr. Bottomley), and R21/R33HL89029 (to Dr. Kraitchman). Drs. Bottomley and Sathyanarayana are coinventors of a patent on the technology filed by Johns Hopkins University and licensed to SurgiVision, Inc., a Johns Hopkins University start-up company with which Dr. Bottomley has a financial relationship that is managed in accordance with the University's conflict-of-interest policies. Drs. Schär and Kraitchman report that they have no relationships to disclose.
Section Editor: Amir Lerman, MD
- Received May 20, 2010.
- Revision received August 6, 2010.
- Accepted August 23, 2010.
- American College of Cardiology Foundation