Author + information
- Received May 29, 2009
- Revision received August 6, 2009
- Accepted September 17, 2009
- Published online February 1, 2010.
- Thomas R. Porter, MD⁎ ( and )
- Feng Xie, MD
- ↵⁎Reprint requests and correspondence:
Dr. Thomas R. Porter, University of Nebraska Medical Center, Cardiology, 981165 Nebraska Medical Center, Omaha, Nebraska 68198-1165
This report reviews the development and clinical application of myocardial perfusion imaging with myocardial contrast echocardiography (MCE). This includes the development of microbubble formulations that permit the detection of left ventricular contrast from venous injection and the imaging techniques that have been invented to detect the transit of these microbubbles through the microcirculation. The methods used to quantify myocardial perfusion during a continuous infusion of microbubbles are described. A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed.
Dr. Porter has received modest grant support from Lantheus Medical Imaging and Astellas Pharma Inc., significant grant support from NuVox Pharma Inc., and other grant support (i.e., equipment, drugs, and software) from Siemens Medical Imaging, and has served as a consultant or received honorarium from Lantheus Medical Imaging and Point BioMed. Sanjiv Kaul, MD, served as Guest Editor for this paper.
- Received May 29, 2009.
- Revision received August 6, 2009.
- Accepted September 17, 2009.
- American College of Cardiology Foundation