Author + information
- Jason L. Quill, PhD⁎,
- Alexander J. Hill, PhD⁎,
- Ana R. Menk, BS⁎,
- Brian T. McHenry, MS⁎ and
- Paul A. Iaizzo, PhD†,⁎ ()
- ↵⁎Address for correspondence:
Dr. Paul A. Iaizzo, University of Minnesota, B172 Mayo, MMC 195, 420 Delaware St. SE, Minneapolis, Minnesota 55455
NOVEL IMAGING OF FUNCTIONAL CARDIAC ANATOMY is possible in isolated heart preparations when a clear perfusate is used; which, in turn, provides important insights into the device-tissue interface of implanted devices such as transcatheter valves. The implantation of a transcatheter aortic valve (TAV) (CoreValve System, Medtronic, Inc., Mounds View, Minnesota) within an isolated human heart was performed using echocardiography, fluoroscopy, and direct visualization to compare imaging modalities for better understanding of the implantation procedure (Fig. 1, Online Video 1).
Endoscopic cameras (IplexFX, Olympus Corporation, Tokyo, Japan) were placed within the ascending aorta and left ventricle of a human donor heart (LifeSource, St. Paul, Minnesota) that was deemed not viable for transplantation. The heart was reanimated and perfused with a clear Krebs-Henseleit buffer according to previously described methodologies (1). Epicardial echo measurements were performed using a transthoracic probe (Vivid i, GE Healthcare, Waukesha, Wisconsin). These images have tremendous educational value for patients, clinicians, and design engineers.
CoreValve is not available for sale in the United States. CoreValve is a registered trademark of Medtronic, Inc. This work was funded by the Institute for Engineering in Medicine at the University of Minnesota and by Medtronic, Inc. Drs. Quill, Hill, Menk, and McHenry are employed by and have ownership interest in Medtronic, Inc., the maker and registered trademark holder of CoreValve. Dr. Iaizzo has consulted for and received research support from Medtronic, Inc.
- American College of Cardiology Foundation