Author + information
- Received June 18, 2010
- Revision received November 22, 2010
- Accepted November 29, 2010
- Published online March 1, 2011.
- Mark J. Boogers, MD⁎,†,
- Jacob M. van Werkhoven, MSc⁎,†,
- Joanne D. Schuijf, PhD⁎,
- Victoria Delgado, MD⁎,
- Heba M. El-Naggar, MD⁎,
- Eric Boersma, PhD‡,
- Gaetano Nucifora, MD⁎,
- Rob J. van der Geest, MSc§,
- Bernard P. Paelinck, MD, PhD∥,
- Lucia J. Kroft, MD, PhD§,
- Johan H.C. Reiber, PhD§,
- Albert de Roos, MD, PhD§,
- Jeroen J. Bax, MD, PhD⁎ and
- Hildo J. Lamb, MD, MSc, PhD§,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Hildo J. Lamb, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands C2-S
Objectives This study aimed to demonstrate the feasibility of multidetector row computed tomography (CT) for assessment of diastolic function in comparison with 2-dimensional (2D) echocardiography using tissue Doppler imaging (TDI).
Background Diastolic left ventricular (LV) function plays an important role in patients with cardiovascular disease. 2D echocardiography using TDI has been used most commonly to evaluate diastolic LV function. Although the role of cardiac CT imaging for evaluation of coronary atherosclerosis has been explored extensively, its feasibility to evaluate diastolic function has not been studied.
Methods Patients who had undergone 64-multidetector row CT and 2D echocardiography with TDI were enrolled. Diastolic function was evaluated using early (E) and late (A) transmitral peak velocity (cm/s) and peak mitral septal tissue velocity (Ea; cm/s). Peak transmitral velocity (cm/s) was calculated by dividing peak diastolic transmitral flow (ml/s) by the corresponding mitral valve area (cm2). Mitral septal tissue velocity was calculated from changes in LV length per cardiac phase. Subsequently, the estimation of LV filling pressures (E/Ea) was determined.
Results Seventy patients (46 men; mean age 55 ± 11 years) who had undergone cardiac CT and 2D echocardiography with TDI were included. Good correlations were observed between cardiac CT and 2D echocardiography for assessment of E (r = 0.73; p < 0.01), E/A (r = 0.87; p < 0.01), Ea (r = 0.82; p < 0.01), and E/Ea (r = 0.81; p < 0.01). Moreover, a good diagnostic accuracy (79%) was found for detection of diastolic dysfunction using cardiac CT. Finally, the study showed a low intraobserver and interobserver variability for assessment of diastolic function on cardiac CT.
Conclusions Cardiac CT imaging showed good correlations for transmitral velocity, mitral septal tissue velocity, and estimation of LV filling pressures when compared with 2D echocardiography. Additionally, cardiac CT and 2D echocardiography were comparable for assessment of diastolic dysfunction. Accordingly, cardiac CT may provide information on diastolic dysfunction.
Dr. Boogers is supported by the Dutch Heart Foundation (grant 2006T102). Dr. van Werkhoven is financially supported by the Netherlands Society of Cardiology. Dr. Delgado has consulted for St. Jude Medical. Dr. Nucifora received a research grant from the European Society of Cardiology. Dr. van der Geest is a consultant for Medis Medical Imaging Systems. Dr. Bax received research grants from Medtronic, Boston Scientific, Biotronik, Edwards Lifesciences, Bristol-Myers Squibb Medical Imaging, St. Jude Medical, and GE Healthcare. All other authors have reported that they have no relationships to disclose.
- Received June 18, 2010.
- Revision received November 22, 2010.
- Accepted November 29, 2010.
- American College of Cardiology Foundation