Author + information
- Received December 14, 2010
- Revision received March 14, 2011
- Accepted March 21, 2011
- Published online May 1, 2011.
- Szilard Voros, MD⁎,⁎ (, )
- Sarah Rinehart, MD⁎,
- Zhen Qian, PhD⁎,
- Parag Joshi, MD⁎,
- Gustavo Vazquez, MD⁎,
- Collin Fischer, MD†,
- Pallavi Belur, DO†,
- Edward Hulten, MD, MPH† and
- Todd C. Villines, MD†
- ↵⁎Reprint requests and correspondence:
Dr. Szilard Voros, Piedmont Heart Institute, 1968 Peachtree Road, NW, Atlanta, Georgia 30309
Coronary computed tomography angiography (CTA) allows coronary artery visualization and the detection of coronary stenoses. In addition; it has been suggested as a novel, noninvasive modality for coronary atherosclerotic plaque detection, characterization, and quantification. Emerging data show that coronary CTA–based semiquantitative plaque characterization and quantification are sufficiently reproducible for clinical purposes, and fully quantitative approaches may be appropriate for use in clinical trials. Furthermore, several lines of investigation have validated plaque imaging by coronary CTA against other imaging modalities such as intravascular ultrasound/“virtual histology” and optical coherence tomography, and there are emerging data using biochemical modalities such as near-infrared spectroscopy. Finally, clinical validation in patients with acute coronary syndrome and in the outpatient setting has shown incremental value of CTA-based plaque characterization for the prediction of major cardiovascular events. With recent developments in image acquisition and reconstruction technologies, coronary CTA can be performed with relatively low radiation exposure. With further technological innovation and clinical research, coronary CTA may become an important tool in the quest to identify vulnerable plaques and the at-risk patient.
- coronary computed tomography angiography
- intravascular ultrasound
- near-infrared spectroscopy
- plaque imaging
Dr. Voros has received research grants from for Abbott Vascular, Volcano Inc., Vital Images, Siemens Medical Solutions, and Toshiba America Medical Systems. All other authors have reported that they have no relationships to disclose.
- Received December 14, 2010.
- Revision received March 14, 2011.
- Accepted March 21, 2011.
- American College of Cardiology Foundation
- Coronary Plaque Imaging by Coronary CTA
- Qualitative Plaque Characterization
- Quantitative Plaque Characterization
- Predictive Value of Plaque Characterization by Coronary CTA
- Serial Imaging: Changes in Plaque Over Time and Effect of Therapy
- Summary, Conclusions, and Future Directions