Author + information
- Received February 25, 2011
- Revision received April 14, 2011
- Accepted April 21, 2011
- Published online June 1, 2011.
- Patricia K. Nguyen, MD⁎,⁎ (, )
- Masahiro Terashima, MD, PhD⁎,
- Joan M. Fair, ANP, PhD⁎,
- Ann Varady, MS⁎,
- Ruth E. Taylor-Piliae, PhD, RN⁎,
- Carlos Iribarren, MD, MPH, PhD†,
- Alan S. Go, MD†,
- William L. Haskell, MD⁎,
- Mark A. Hlatky, MD⁎,
- Stephen P. Fortmann, MD⁎ and
- Michael V. McConnell, MD, MSEE⁎
- ↵⁎Reprint requests and correspondence:
Dr. Patricia K. Nguyen, Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRB, Stanford, California 94305
Objectives We investigated the association between physical activity and coronary vasodilation to nitroglycerin (NTG) in the ADVANCE (Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology) cohort of older healthy subjects.
Background Physical activity may exert its beneficial effects by augmenting coronary responsiveness to nitric oxide. The relationship between physical activity and coronary vasodilatory response to NTG, an exogenous nitric oxide donor, has not been studied in a community-based population with typical activity levels.
Methods In 212 older adults (ages 60 to 72 years) without cardiovascular disease, we measured the coronary vasodilatory response to NTG using magnetic resonance angiography and physical activity using the Stanford Seven-Day Physical Activity Recall Questionnaire. The primary predictor measure was total physical activity (kcal/kg/day). The primary outcome measure was coronary vasodilatory response (percent increase of cross-sectional area post-NTG).
Results Coronary vasodilation was 27.6% in more active subjects (>35 kcal/kg/day, e.g., 1 h of walking per day) compared to 18.9% in less active subjects (p = 0.03). Regression analysis showed a significant positive correlation between coronary vasodilation and physical activity (p = 0.003), with a slope (beta) of 1.2% per kcal/kg/day. This finding remained significant after adjustment for cardiac risk factors, coronary calcium, the use of vasoactive or statin medications, and analysis of physical activity by quintiles (p < 0.05). Coronary vasodilation was also associated with physical activity intensity (p = 0.03).
Conclusions In an asymptomatic, community-based cohort of older adults, increased coronary vasodilatory response was independently associated with greater physical activity, supporting the benefits of exercise on the order of 1 h of walking per day.
The Donald W. Reynolds Foundation, National Institutes of Health, the American College of Cardiology (ACC/Merck grant), and GE Healthcare supported this research. Dr. McConnell's laboratory receives research support from GE Healthcare, Inc., and is on the scientific advisory board for Kowa, Inc. All other authors have reported they have no relationships to disclose.
- Received February 25, 2011.
- Revision received April 14, 2011.
- Accepted April 21, 2011.
- American College of Cardiology Foundation