Author + information
- Received October 18, 2010
- Revision received March 7, 2011
- Accepted March 14, 2011
- Published online June 1, 2011.
- Salvatore Brugaletta, MD⁎,†,
- Hector M. Garcia-Garcia, MD, PhD⁎,‡,
- Patrick W. Serruys, MD, PhD⁎,⁎ (, )
- Sanneke de Boer, MD⁎,
- Jurgen Ligthart, BSc⁎,
- Josep Gomez-Lara, MD⁎,
- Karen Witberg, RN⁎,
- Roberto Diletti, MD⁎,
- Joanna Wykrzykowska, MD⁎∥,
- Robert-Jan van Geuns, MD, PhD⁎,
- Carl Schultz, MD⁎,
- Evelyn Regar, MD, PhD⁎,
- Henricus J. Duckers, MD, PhD⁎,
- Nicolas van Mieghem, MD⁎,
- Peter de Jaegere, MD, PhD⁎,
- Sean P. Madden, PhD§,
- James E. Muller, MD, PhD§,
- Antonius F.W. van der Steen, PhD⁎,
- Wim J. van der Giessen, MD, PhD⁎ and
- Eric Boersma, PhD⁎
- ↵⁎Reprint requests and correspondence:
Dr. Patrick W. Serruys, Thoraxcenter, Ba-583, ‘s Gravendijkwal 230, 3015 CE, Rotterdam, the Netherlands
Objectives The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography.
Background Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP).
Methods We performed NIRS and IVUS-VH pullbacks in a consecutive series of 31 patients with a common region of interest (ROI) between 2 side branches. For each ROI, we analyzed the chemogram blocks by NIRS, plaque area and plaque burden by grayscale IVUS, and tissue types by IVUS-VH. The chemogram block is a summary metric of a 2-mm vertical slice of the chemogram. The value ranges from 0 to 1 according to the presence of lipids and represents the probability of LCP with a color scale from red (low probability) through orange and tan to yellow (high probability).
Results Plaque area (mm2) increases as percentage VH derived-necrotic core (NC) content (4.6 ± 2.7 vs. 7.4 ± 3.5 vs. 8.6 ± 3.4 vs. 7.9 ± 3.3, grouped in percentage NC quartiles, p < 0.001) and chemogram block probability color bin thresholds increase (4.9 ± 3.8 red, 7.3 ± 3.6 orange, 8.1 ± 3.4 tan, and 8.7 ± 3.4 yellow, p < 0.001). The correlation between the block chemogram detection of lipid core and percentage NC content by VH was weak (r = 0.149). Correction for the presence of calcium does not improve this correlation.
Conclusions Larger plaque area by grayscale IVUS was more often associated with either elevated percentage VH-NC or LCP by NIRS; however, the correlation between the detection of LCP by NIRS and necrotic core by VH is weak.
Drs. Muller and Madden are current employees of InfraReDx, Inc. All other authors have reported that they have no relationships to disclose.
- Received October 18, 2010.
- Revision received March 7, 2011.
- Accepted March 14, 2011.
- American College of Cardiology Foundation