Author + information
- Received January 24, 2011
- Revision received May 9, 2011
- Accepted May 9, 2011
- Published online July 1, 2011.
- Michael D. Hope, MD⁎,⁎ (, )
- Thomas A. Hope, MD⁎,
- Stephen E.S. Crook, BA⁎,
- Karen G. Ordovas, MD⁎,
- Thomas H. Urbania, MD⁎,
- Marc T. Alley, PhD† and
- Charles B. Higgins, MD⁎
- ↵⁎Reprint requests and correspondence
: Dr. Michael D. Hope, Department of Radiology, University of California-San Francisco, 505 Parnassus Avenue, Box 0628, San Francisco, California 94143-0628
Blood flow imaging with 3-dimensional time-resolved, phase-contrast cardiac magnetic resonance (4-dimensional [4D] Flow) is an innovative and visually appealing method for studying cardiovascular disease that allows quantification of important secondary vascular parameters including wall shear stress. The hypothesis of this pilot study is that 4D Flow will become a powerful tool for characterizing the relationship of aortic valve–related flow dynamics, especially with bicuspid aortic valve (BAV), and progression of ascending aortic (AsAo) dilation. We identified 46 patients previously studied with 4D Flow: tricuspid aortic valve patients without valvular disease (n = 20), and BAV patients with either normal flow (n = 7) or eccentric systolic jets resulting in abnormal right-handed helical AsAo flow (n = 19). The subgroup of patients with BAV and eccentric systolic AsAo blood flow was found to have significantly and asymmetrically elevated wall shear stress. This increased hemodynamic burden may place them at risk for AsAo aneurysm.
This work was funded by the Radiologic Society of North America Resident Research Grant 2008–2009. Dr. Alley receives grant and research funding from GE Healthcare. All other authors have reported that they have no relationships to disclose.
- Received January 24, 2011.
- Revision received May 9, 2011.
- Accepted May 9, 2011.
- American College of Cardiology Foundation