Author + information
- Received May 11, 2010
- Revision received March 4, 2011
- Accepted March 14, 2011
- Published online September 1, 2011.
- Melissa J. Suter, PhD⁎,†,
- Seemantini K. Nadkarni, PhD⁎,‡,
- Giora Weisz, MD§,
- Atsushi Tanaka, MD, PhD⁎,‡,
- Farouc A. Jaffer, MD, PhD⁎∥,
- Brett E. Bouma, PhD⁎,‡,¶ and
- Guillermo J. Tearney, MD, PhD⁎,¶,#,⁎ ()
- ↵⁎Reprint requests and correspondence
: Dr. Guillermo J. Tearney, Massachusetts General Hospital, Wellman Center for Photomedicine, 40 Blossom Street, BAR 701, Boston, Massachusetts 02114
There is an ever-increasing demand for new imaging methods that can provide additional information about the coronary wall to better characterize and stratify high-risk plaques, and to guide interventional and pharmacologic management of patients with coronary artery disease. While there are a number of imaging modalities that facilitate the assessment of coronary artery pathology, this review paper focuses on intravascular optical imaging modalities that provide information on the microstructural, compositional, biochemical, biomechanical, and molecular features of coronary lesions and stents. The optical imaging modalities discussed include angioscopy, optical coherence tomography, polarization sensitive-optical coherence tomography, laser speckle imaging, near-infrared spectroscopy, time-resolved laser induced fluorescence spectroscopy, Raman spectroscopy, and near-infrared fluorescence molecular imaging. Given the wealth of information that these techniques can provide, optical imaging modalities are poised to play an increasingly significant role in the evaluation of the coronary artery in the future.
Dr. Suter is supported by National Institutes of Health (NIH) grant R00CA134920. Dr. Nadkarni is supported by NIH grants R21HL088306 and R21HL089203. NIH grants R01HL076398 and R01HL093717 support the cardiovascular imaging research in the laboratory of Drs. Bouma and Tearney; and the Terumo Corporation, Tokyo, Japan, supports the nonclinical cardiovascular imaging research in the laboratory of Drs. Bouma and Tearney. Dr. Jaffer has received honoraria from Boston Scientific. All other authors have reported they have no relationships relevant to the contents of this paper to disclose.
- Received May 11, 2010.
- Revision received March 4, 2011.
- Accepted March 14, 2011.
- American College of Cardiology Foundation