Author + information
- Received October 11, 2010
- Revision received February 15, 2011
- Accepted February 24, 2011
- Published online September 1, 2011.
- Georg Fuernau, MD⁎,⁎ (, )
- Ingo Eitel, MD⁎,
- Vinzenz Franke, BSc⁎,
- Lysann Hildebrandt, BSc⁎,
- Josefine Meissner, BSc⁎,
- Suzanne de Waha, MD⁎,
- Philipp Lurz, MD⁎,
- Matthias Gutberlet, MD†,
- Steffen Desch, MD⁎,
- Gerhard Schuler, MD⁎ and
- Holger Thiele, MD⁎
- ↵⁎Reprint requests and correspondence:
Dr. Georg Fuernau, University of Leipzig—Heart Center, Department of Internal Medicine—Cardiology, Strümpellstraße 39, 04289 Leipzig, Germany
Objectives The objective of this study was to assess the area at risk (AAR) in ST-segment elevation myocardial infarction with 2 different cardiac magnetic resonance (CMR) imaging methods and to compare them with the validated angiographic Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease Score (APPROACH-score) in a large consecutive patient cohort.
Background Edema imaging with T2-weighted CMR and the endocardial surface area (ESA) assessed by late gadolinium enhancement have been introduced as relatively new methods for AAR assessment in ST-segment elevation myocardial infarction. However, data on the utility and validation of these techniques are limited.
Methods A total of 197 patients undergoing primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction were included. AAR (assessed with T2-weighted edema imaging and the ESA method), infarct size, and myocardial salvage (AAR minus infarct size) were determined by CMR 2 to 4 days after primary angioplasty. Angiographic AAR scoring was performed by use of the APPROACH-score. All measurements were done offline by blinded observers.
Results The AAR assessed by T2-weighted imaging showed good correlation with the angiographic AAR (r = 0.87; p < 0.001), whereas the ESA showed only a moderate correlation either to T2-weighted imaging (r = 0.56; p < 0.001) or the APPROACH-score (r = 0.44; p < 0.001). Mean AAR by ESA (20.0 ± 11.7% of left ventricular mass) was significantly (p < 0.001) smaller than the AAR assessed by T2-weighted imaging (35.6 ± 10.9% of left ventricular mass) or the APPROACH-score (27.9 ± 10.5% of left ventricular mass) and showed a significant negative dependence on myocardial salvage index. In contrast, no dependence of T2-weighted edema imaging or the APPROACH-score on myocardial salvage index was seen.
Conclusions The AAR can be reliably assessed by T2-weighted CMR, whereas assessment of the AAR by ESA seems to be dependent on the degree of myocardial salvage, thereby underestimating the AAR in patients with high myocardial salvage such as aborted infarction. Thus, assessment of the AAR with the ESA method cannot be recommended. (Myocardial Salvage and Contrast Dye Induced Nephropathy Reduction by N-Acetylcystein [LIPSIA-N-ACC]; NCT00463749)
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received October 11, 2010.
- Revision received February 15, 2011.
- Accepted February 24, 2011.
- American College of Cardiology Foundation