Author + information
- Received May 19, 2011
- Revision received July 22, 2011
- Accepted August 2, 2011
- Published online January 1, 2012.
- Jaydev K. Dave, MS⁎,§,
- Valgerdur G. Halldorsdottir, MS⁎,§,
- John R. Eisenbrey, PhD⁎,
- Joel S. Raichlen, MD†,
- Ji-Bin Liu, MD⁎,
- Maureen E. McDonald, MBA, RDCS, RDMS‡,
- Kris Dickie, BTech∥,
- Shumin Wang, MD⁎,
- Corina Leung, MASc∥ and
- Flemming Forsberg, PhD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Flemming Forsberg, Department of Radiology, Suite 763J, Main Building, 132 South 10th Street, Philadelphia, Pennsylvania 19107
To develop a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles, an ultrasound scanner was used in pulse inversion grayscale mode; unprocessed radiofrequency data were obtained with pulsed wave Doppler from the aorta and/or LV during Sonazoid infusion. Subharmonic data (in dB) were extracted and processed. Calibration factor (mm Hg/dB) from the aortic pressure was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mm Hg when estimating pressures using the aortic calibration factor, and were higher (0.64 to 8.98 mm Hg) using a mean aortic calibration factor. Subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.
This study was supported by American Heart Association grant 0655441U, Dallas, Texas; National Institutes of Health grants R21 HL081892 and RC1 DK087365 (to Dr. Eisenbrey), Bethesda, Maryland; and US Army Medical Research & Material Command grant W81XWH-08-1-0503 (to Ms. Halldorsdottir), Fort Detrick, Maryland. Mr. Dickie and Ms. Leung are employees of Ultrasonix Medical Corporation. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received May 19, 2011.
- Revision received July 22, 2011.
- Accepted August 2, 2011.
- American College of Cardiology Foundation