Author + information
- Received February 24, 2011
- Revision received August 1, 2011
- Accepted August 2, 2011
- Published online February 1, 2012.
- Sanjaya Gupta, MD⁎,
- Benoit Desjardins, MD, PhD†,
- Timir Baman, MD⁎,
- Karl Ilg, MD⁎,
- Eric Good, DO⁎,
- Thomas Crawford, MD⁎,
- Hakan Oral, MD⁎,
- Frank Pelosi, MD⁎,
- Aman Chugh, MD⁎,
- Fred Morady, MD⁎ and
- Frank Bogun, MD⁎,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Frank Bogun, Cardiovascular Center, SPC 5853, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-5853
Post-infarction arrhythmias are most often confined to scar tissue. Scar can be detected by delayed-enhanced cardiac magnetic resonance. The purpose of this study was to assess the feasibility of pre-procedural scar identification and intraprocedural real-time image registration with an electroanatomical map in 23 patients with previous infarction and ventricular arrhythmias (VAs). Registration accuracy and cardiac magnetic resonance/electroanatomical map correlations were assessed, and critical areas for VA were correlated with the presence of scar. With a positional registration error of 3.8 ± 0.8 mm, 86% of low-voltage points of the electroanatomical map projected onto the registered scar. The delayed-enhanced cardiac magnetic resonance–defined scar correlated with the area of low voltage (R = 0.82, p < 0.001). All sites critical to VAs projected on the registered scar. Selective identification and extraction of delayed-enhanced cardiac magnetic resonance defined scar followed by registration into a real-time mapping system are feasible and help to identify and display the arrhythmogenic substrate in post-infarction patients with VAs.
Dr. Desjardins has received an NIH grant (K23 EB006481). Drs. Oral and Bogun have received a grant from the Leducq Foundation. Dr. Bogun has participated in a catheter study by Biosense Webster. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received February 24, 2011.
- Revision received August 1, 2011.
- Accepted August 2, 2011.
- American College of Cardiology Foundation