|Absolute Contraindication||Relative Contraindication||No Contraindication|
|Left atrial thrombus||Active peptic ulcer||Isolated left atrial appendage thrombus|
|Recent (<3 weeks) ischemic stroke||Blood pressure >180/110 mm Hg||Acute (<4 h) or previous (>3 weeks) ischemic stroke⁎|
|Hemorrhagic stroke||INR 2–3†||INR <2|
|Early (<4 days) post-operative period||Recent (<4 wk) internal bleed||Late (>4 days) post-operative period|
|Traumatic accident <4 weeks||Previous SKZ therapy (5 days to 2 yrs)||Pregnancy|
|Bleeding diathesis‡||Recent CPR|
|Intracranial mass||Infective endocarditis|
|Active internal bleed||Hemorrhagic retinopathy|
CPR = cardiopulmonary resuscitation; INR = international normalized ratio; SKZ = streptokinase.
↵⁎ Patients with hemorrhagic conversion of cerebral infarction on the neuroradiological study were not included.
↵† INR levels represent the samples obtained at the time that the thrombolytic treatment decision was made. Thrombolytic agents were administered to the patients with an INR between 2 and 3 when the clinical setting was appropriate to avoid treatment delays.
↵‡ Patients with acquired/congenital bleeding diathesis or an INR >3.