Author + information
- Received April 11, 2014
- Revision received June 19, 2014
- Accepted July 11, 2014
- Published online November 1, 2014.
- Min Li, MD,
- Tao Zhou, MD,
- Lin-feng Yang, MD,
- Zhao-hui Peng, MD,
- Juan Ding, MD and
- Gang Sun, MD, PhD∗ ()
- ↵∗Reprint requests and correspondence:
Dr. Gang Sun, Department of Medical Imaging, Jinan Military General Hospital, No. 25, Shifan Road, Jinan, Shandong Province 250031, China.
Objectives This paper systematically analyzed the performance of magnetic resonance (MR) perfusion to diagnose coronary artery disease (CAD) with fractional flow reserve (FFR) as the reference standard.
Background Myocardial MR perfusion has passed the stage of a research technique and has demonstrated the ability to detect functional or ischemic stenosis of coronary arteries. However, the evidence is limited to single-center studies and small sample sizes.
Methods We searched PubMed and Embase databases for all published studies that evaluated the accuracy of MR perfusion to diagnose CAD versus FFR. We used an exact binomial rendition of the bivariate mixed-effects regression model with test type as a random-effects covariate to synthesize the available data. Based on Bayes’ theorem, the post-test probability was calculated to guide MR perfusion’s clinical utility.
Results We identified 14 studies evaluating 1,073 arteries and 650 patients. The pooled sensitivity and specificity were 0.90 (95% confidence interval [CI]: 0.86 to 0.93) and 0.87 (95% CI: 0.82 to 0.90) at the patient level and 0.89 (95% CI: 0.83 to 0.92) and 0.86 (95% CI: 0.77 to 0.92) at the artery and territory levels, respectively. The area under the summary receiver-operating characteristic at the patient level was 0.95 (95% CI: 0.92 to 0.96) and 0.93 (95% CI: 0.91 to 0.95) at the artery and territory levels, respectively. MR perfusion could increase the post-test probability of CAD >80% in patients with a pre-test probability of >37% and can decrease post-test probability of CAD <20% with a pre-test probability of <72%.
Conclusions With FFR as the reference standard, the diagnostic ability of MR perfusion to detect ischemic CAD is high.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 11, 2014.
- Revision received June 19, 2014.
- Accepted July 11, 2014.
- American College of Cardiology Foundation