Author + information
- Received April 10, 2014
- Revision received July 9, 2014
- Accepted August 6, 2014
- Published online November 1, 2014.
- Sergey V. Nesterov, MD, PhD, PMP∗,†∗ (, )
- Emmanuel Deshayes, MD, MSc‡,§,
- Roberto Sciagrà, MD‖,
- Leonardo Settimo, MD‖,
- Jerome M. Declerck, PhD¶,
- Xiao-Bo Pan, PhD¶,
- Keiichiro Yoshinaga, MD, PhD#,
- Chietsugu Katoh, MD, PhD#,
- Piotr J. Slomka, PhD∗∗,
- Guido Germano, PhD∗∗,
- Chunlei Han, MD, PhD∗,
- Ville Aalto, MSc∗,
- Adam M. Alessio, PhD††,
- Edward P. Ficaro, PhD‡‡,
- Benjamin C. Lee, PhD§§,
- Stephan G. Nekolla, PhD‖‖,
- Kilem L. Gwet, PhD¶¶,
- Robert A. deKemp, PhD, PEng, PPhys##,
- Ran Klein, PhD##,
- John Dickson, PhD∗∗∗,
- James A. Case, MD, PhD†††,
- Timothy Bateman, MD, PhD†††,
- John O. Prior, MD, PhD‡ and
- Juhani M. Knuuti, MD, PhD∗
- ∗Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
- †IM Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia
- ‡Lausanne University Hospital, Lausanne, Switzerland
- §Regional Cancer Institute of Montpellier (ICM)—Val d’Aurelle, Montpellier, France
- ‖University of Florence, Florence, Italy
- ¶Siemens Molecular Imaging, Oxford, United Kingdom
- #Hokkaido University Graduate School of Medicine, Sapporo, Japan
- ∗∗Cedars-Sinai Medical Center, Los Angeles, California
- ††University of Washington, Seattle, Washington
- ‡‡University of Michigan Health Systems, Ann Arbor, Michigan
- §§INVIA Medical Imaging Solutions, Ann Arbor, Michigan
- ‖‖Department of Nuclear Medicine, Technical University, Munich, Germany
- ¶¶Advanced Analytics LLC, Gaithersburg, Maryland
- ##National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
- ∗∗∗University College London, London, United Kingdom
- †††Cardiovascular Imaging Technologies, Kansas City, Missouri
- ↵∗Reprint requests and correspondence:
Dr. Sergey V. Nesterov, University of Turku and Turku University Hospital, Turku PET Centre, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Objectives The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography (82Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.
Background It is unknown how MBF and MFR values from existing SPs agree for 82Rb PET.
Methods Rest and stress 82Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.
Results The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.
Conclusions SPs using the most common kinetic model—OHI-1-TCM—provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.
This study was conducted within the Finnish Centre of Excellence in Cardiovascular and Metabolic Diseases supported by the Academy of Finland, University of Turku, Turku University Hospital, and Åbo Akademi University; and was supported in part by grants from the Japanese Ministry of Education, Science and Culture (No. 1959135), Northern Advancement Center for Science & Technology (H23-S2-17), and the U.S. National Institutes of Health grant K25-HL086713. Cedars-Sinai receives royalties from the licensing of QPET software, a minority of which is shared with developers, including Drs. Slomka and Germano. Dr. Slomka has received grant support from Siemens Healthcare. Dr. Alessio has received a research grant from GE Healthcare; and has served as a consultant for Lantheus Medical Imaging. Dr. Ficaro has received revenue shares from the sale of Corridor4DM and is the owner of INVIA Medical Imaging Solutions. Dr. Lee has received financial support from and is an employee of INVIA Medical Imaging Solutions. Drs. deKemp and Klein have received revenue shares from the sale of FlowQuant; and have served as consultants to and received revenue shares from Jubilant-DraxImage. Dr. deKemp has received royalties from technologies licensed to Jubilant DraxImage and INVIA Medical Imaging Solutions. Drs. Case and Bateman are owners of Cardiovascular Imaging Technologies, which licenses and sells ImagenQ. Dr. Bateman has served on the advisory board of Lantheus Medical Imaging, GE, and FluoroPharma. Dr. Knuuti has served as a consultant to Lantheus Medical Imaging. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Nesterov and Deshayes contributed equally to this work as first authors. Drs. Prior and Knuuti contributed equally to this work as senior authors.
- Received April 10, 2014.
- Revision received July 9, 2014.
- Accepted August 6, 2014.
- American College of Cardiology Foundation