Author + information
- Received April 21, 2014
- Revision received June 25, 2014
- Accepted June 29, 2014
- Published online September 1, 2014.
- Yasmin S. Hamirani, MD∗,
- Andrew Wong, BS†,
- Christopher M. Kramer, MD∗,‡ and
- Michael Salerno, MD, PhD∗,‡∗ ()
- ∗Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia
- †University of Virginia School of Medicine, Charlottesville, Virginia
- ‡Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, Virginia
- ↵∗Reprint requests and correspondence:
Dr. Michael Salerno, University of Virginia Health System, 1215 Lee Street, Box 800170, Charlottesville, Virginia 22908.
The goal of this systematic analysis is to provide a comprehensive review of the current cardiac magnetic resonance data on microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH). Data related to the association of MVO and IMH in patients with acute myocardial infarction (MI) with left ventricular (LV) function, volumes, adverse LV remodeling, and major adverse cardiac events (MACE) were critically analyzed. MVO is associated with a lower ejection fraction, increased ventricular volumes and infarct size, and a greater risk of MACE. Late MVO is shown to be a stronger prognostic marker for MACE and cardiac death, recurrent MI, congestive heart failure/heart failure hospitalization, and follow-up LV end-systolic volumes than early MVO. IMH is associated with LV remodeling and MACE on pooled analysis, but because of limited data and heterogeneity in study methodology, the effects of IMH on remodeling require further investigation.
- cardiac magnetic resonance
- ejection fraction
- intramyocardial hemorrhage
- left ventricular remodeling
- microvascular obstruction
Dr. Kramer has received research support from Siemens Medical Systems and is a consultant to Synarc. Dr. Salerno has received research support from Siemens Medical Systems and the National Institutes of Health K23 HL112910-01. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 21, 2014.
- Revision received June 25, 2014.
- Accepted June 29, 2014.