Author + information
- Received April 30, 2014
- Revision received August 26, 2014
- Accepted August 27, 2014
- Published online January 1, 2015.
- Ana García-Álvarez, MD, PhD∗,†,‡∗ ( )(, )
- Inés García-Lunar, MD∗,†,§,
- Daniel Pereda, MD∗,†,‡,
- Rodrigo Fernández-Jimenez, MD∗,†,‖,
- Javier Sánchez-González, PhD∗,†,¶,
- Jesús G. Mirelis, MD, PhD∗,†,#,
- Mario Nuño-Ayala, PhD∗,†,
- Damian Sánchez-Quintana, MD∗∗,
- Leticia Fernández-Friera, MD, PhD∗,†,††,
- Jose M. García-Ruiz, MD∗,†,‡‡,
- Gonzalo Pizarro, MD∗,†,§,
- Jaume Agüero, MD∗,†,
- Paula Campelos, MD‡,
- Manuel Castellá, MD, PhD‡,
- Manel Sabaté, MD, PhD‡,
- Valentin Fuster, MD, PhD†,§§,
- Javier Sanz, MD§§ and
- Borja Ibañez, MD, PhD∗,†,‖∗ ()
- ∗Imaging in Experimental Cardiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
- †Epidemiology, Atherothrombosis and Imaging Department, CNIC, Madrid, Spain
- ‡Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
- §Hospital Universitario Quirón Madrid, Universidad Europea de Madrid, Madrid, Spain
- ‖Hospital Clínico San Carlos, Madrid, Spain
- ¶Philips Healthcare Iberia, Madrid, Spain
- #Hospital Puerta de Hierro, Madrid, Spain
- ∗∗Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain
- ††Hospital Universitario Montepríncipe, Madrid, Spain
- ‡‡Hospital Universitario Central de Asturias, Oviedo, Spain
- §§Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York
- ↵∗Reprint requests and correspondence:
Dr. Borja Ibáñez or Dr. Ana García-Álvarez, Epidemiology, Atherothrombosis and Imaging Department, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.
This study was partly funded by the “Red de Investigación Cardiovascular” (RIC) of the Spanish Ministry of Health (RD 12/0042/0054 to Dr. Ibáñez) and by ISCIII “Fondo de Investigación Sanitaria” grant PI13 /02339 to Dr. García-Álvarez. Drs. García-Álvarez, Mirelis, Fernández-Friera, Pizarro, and Ibáñez are members of different institutions participating in the RIC. Other sponsors were the Spanish Heart Foundation (basic research project 2012 to Dr. García-Álvarez) and a master research agreement between Philips Healthcare and CNIC. All authors have reported that they have no relationships relevant to the contents of this paper to disclose. The first 2 authors contributed equally to this work. Raymond Kwong, MD, MPH, has served as Guest Editor for this paper.
- Received April 30, 2014.
- Revision received August 26, 2014.
- Accepted August 27, 2014.
- 2015 American College of Cardiology Foundation