Author + information
- Received June 22, 2015
- Revision received September 30, 2015
- Accepted October 8, 2015
- Published online December 1, 2015.
- ∗Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
- †Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium
- ↵∗Reprint requests and correspondence:
Dr. Thomas H. Marwick, Menzies Institute for Medical Research, 17 Liverpool Street, Hobart, Tasmania 7000, Australia.
The outcomes associated with heart failure after myocardial infarction are still poor. Both global and regional left ventricular (LV) remodeling are associated with the progression of the post-infarct patient to heart failure, but although global remodeling can be accurately measured, regional LV remodeling has been more difficult to investigate. Preliminary evidence suggests that post-MI assessment of LV mechanics using stress and strain may predict global (and possibly regional) LV remodeling. A method of predicting both global and regional LV remodeling might facilitate earlier, targeted, and more extensive clinical intervention in those most likely to benefit from novel interventions such as cell therapy.
- ischemic heart disease
- left ventricular curvature
- left ventricular mechanics
- left ventricular remodeling
- left ventricular strain
- left ventricular wall stress
Drs. D’hooge and Marwick have research collaborations with GE Medical Systems and Philips. Neither company had any role in the inception or preparation of this manuscript. Dr. Marwick has a research collaboration with Philips; and has received research grants from GE Medical Systems. Mr. D’Elia has reported that he has no relationships relevant to the contents of this paper to disclose.
- Received June 22, 2015.
- Revision received September 30, 2015.
- Accepted October 8, 2015.
- 2015 American College of Cardiology Foundation