|First Author, Year (Ref. #)||Imaging or Intervention Used||Sample Size||Patient Population||Main Findings|
|Li et al., 2013 (35)||Angiography, FFR||N = 1,090|
|Consecutive patients referred for PCI and undergoing FFR measurement.||Women had an adjusted FFR value of 0.011 points higher than in men. When categorized by diameter stenosis, FFR values were significantly higher in women vs. men for lesions with angiographic stenosis between 60—69% and 70—79%.|
|Kang et al., 2013 (36)||Angiography, IVUS, FFR||N = 700|
|Prospective observational registry: consecutive patients undergoing angiography, IVUS, and FFR with a proximal or mid LAD lesion and >30% diameter stenosis on visual assessment.||For any given stenosis women demonstrated higher FFR than men.|
MLA cutoff of 2.45 mm2 in women and 2.53 mm2 in men best predicted FFR <0.80.
The incidence of IVUS-FFR mismatch (MLA ≤2.5 mm2 and FFR ≥0.80) was significantly higher in women (34% vs. 20%, p < 0.001).
The PPV of detecting FFR <0.80 for IVUS MLA of ≤2.5 mm2 was lower in women, 42% vs. 63%.
The PPV of FFR <0.80 for an angiographic diameter stenosis of ≥53% was lower in women, 44% in women vs. 60% in men.
|Kim et al., 2012 (37) (FAME trial substudy)||Angiography, FFR||N = 1,005|
|Patients with multivessel CAD ≥50% diameter stenosis in ≥2 major epicardial vessels, which, based on the angiographic appearance and clinical data, were felt to require PCI. Patients were randomly assigned to either angiography- or FFR-guided PCI.||FFR values were significantly higher in women vs. men (0.75 ± 0.18 vs. 0.71 ± 0.17, p = 0.001)|
Women had fewer intermediate lesions (50% to 70% stenosis) with FFR ≤0.80 compared with men (21.1% vs. 39.5%, p < 0.001).
Women had fewer lesions with 70% to 90% stenosis and FFR ≤0.80 (71.9% vs. 82.0%, p = 0.019) versus men.
FFR vs. angiography guided PCI was equally beneficial in men and women to reduce 2-year MACE.
FFR = fractional flow reserve; LAD = left anterior descending artery; MACE = major adverse cardiac event; PCI = percutaneous coronary intervention; PPV = positive predictive value; other abbreviations as in Table 2.