Author + information
- Received April 5, 2017
- Revision received July 5, 2017
- Accepted July 7, 2017
- Published online September 13, 2017.
- Mari Nieves Velasco Forte, MBBSa,b,c,
- Nick Byrne, MSca,d,
- Israel Valverde, MDa,b,c,
- Gorka Gomez Ciriza, MScb,
- Antony Hermuzi, MBBSc,
- Pimpak Prachasilchai, MDc,
- Gur Mainzer, MBBSc,
- Kuberan Pushparajah, MDa,c,
- Markus Henningsson, PhDa,
- Tarique Hussain, MD, PhDa,e,
- Shakeel Qureshi, MDc and
- Eric Rosenthal, MDc,∗ ()
- aDivision of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom
- bCardiovascular Pathology Unit, Institute of Biomedicine of Seville, IBIS, Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain
- cDepartment of Congenital Heart Disease, Evelina London Children’s Hospital, Guy’s and St Thomas NHS Foundation Trust, London, United Kingdom
- dDepartment of Medical Physics, Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom
- eDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, Texas
- ↵∗Address for correspondence:
Prof. Eric Rosenthal, Evelina London Children’s Hospital, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom.
Sinus venosus atrial septal defects (SVASD) with partial anomalous pulmonary venous drainage (PAPVD) are conventionally treated surgically. Cardiac magnetic resonance (CMR) (Figure 1, Online Video 1), patient-specific 3-dimensional (3D) printing (Online Appendix) and in vitro simulation with rotational x-ray computed tomography (CT) (Figure 2, Online Videos 2 and 3) were used to explore a potential interventional catheterization treatment in 3 adult patients: placement of a custom-made covered Cheatham-Platinum stent in the superior vena cava to right atrium junction to close the SVASD while committing the anomalous pulmonary vein to the left atrium (Figures 3 and 4, Online Videos 4, 5, 6, 7, 8, 9, 10, 11, 12, and 13).
Detailed cross-sectional imaging (CMR or CT) allowed patient-specific 3D printing of the anatomy. Simulation of the procedure gave us confidence that the pulmonary veins would remain patent before the clinical catheterization. Using a rigorous approach to accurately assess the anatomy of the SVASD and the PAPVD, we were able to develop a safe and clinically effective interventional catheterization treatment that was successfully performed in 3 patients (Figure 5).
For an expanded methods section, supplemental figure, and supplemental videos and their legends, please see the online version of this article.
This work was supported by the National Institute for Health Research (NIHR) Cardiovascular Health Technology Cooperative (HTC) and Biomedical Research Center (BRC) awarded to Guy's & St Thomas' NHS Foundation Trust in partnership with King's College London (grant code MRJKAGR). All authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received April 5, 2017.
- Revision received July 5, 2017.
- Accepted July 7, 2017.
- 2017 American College of Cardiology Foundation