Author + information
- Received March 27, 2018
- Accepted March 28, 2018
- Published online June 13, 2018.
- Jeffrey M. Levsky, MD, PhDa,b,∗ (, )
- Linda B. Haramati, MD, MSa,c,
- Daniel M. Spevack, MD, MSb,
- Mark A. Menegus, MDb,
- Terence Chen, MPHa,
- Sarah Mizrachi, BAa,
- Durline Brown-Manhertz, DNPb,
- Samantha Selesny, MDa,
- Rikah Lerer, MDa,
- Deborah J. White, MD, MBAd,
- Jonathan N. Tobin, PhDe,f,
- Cynthia C. Taub, MDb and
- Mario J. Garcia, MDa,b
- aDepartment of Radiology, Division of Cardiothoracic Imaging, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York
- bDepartment of Internal Medicine, Division of Cardiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York
- cDepartment of Internal Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York
- dDepartment of Emergency Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York
- eDepartment of Epidemiology and Population Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York
- fClinical Directors Network (CDN), New York, New York
- ↵∗Address for correspondence:
Dr. Jeffrey M. Levsky, Department of Radiology, Montefiore Medical Center/Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467-2490.
Objectives This study sought to compare early emergency department (ED) use of coronary computed tomography angiography (CTA) and stress echocardiography (SE) head-to-head.
Background Coronary CTA has been promoted as the early ED chest pain triage imaging method of choice, whereas SE is often overlooked in this setting and involves no ionizing radiation.
Methods The authors randomized 400 consecutive low- to intermediate-risk ED acute chest pain patients without known coronary artery disease and a negative initial serum troponin level to immediate coronary CTA (n = 201) or SE (n = 199). The primary endpoint was hospitalization rate. Secondary endpoints were ED and hospital length of stay. Safety endpoints included cardiovascular events and radiation exposure.
Results Mean patient age was 55 years, with 43% women and predominantly ethnic minorities (46% Hispanics, 32% African Americans). Thirty-nine coronary CTA patients (19%) and 22 SE patients (11%) were hospitalized at presentation (difference 8%; 95% confidence interval: 1% to 15%; p = 0.026). Median ED length of stay for discharged patients was 5.4 h (interquartile range [IQR]: 4.2 to 6.4 h) for coronary CTA and 4.7 h (IQR: 3.5 to 6.0 h) for SE (p < 0.001). Median hospital length of stay was 58 h (IQR: 50 to 102 h) for coronary CTA and 34 h (IQR: 31 to 54 h) for SE (p = 0.002). There were 11 and 7 major adverse cardiovascular events for coronary CTA and SE, respectively (p = 0.47), over a median 24 months of follow-up. Median/mean complete initial work-up radiation exposure was 6.5/7.7 mSv for coronary CTA and 0/0.96 mSv for SE (p < 0.001).
Conclusions The use of SE resulted in the hospitalization of a smaller proportion of patients with a shorter length of stay than coronary CTA and was safe. SE should be considered an appropriate option for ED chest pain triage (Stress Echocardiography and Heart Computed Tomography [CT] Scan in Emergency Department Patients With Chest Pain; NCT01384448).
- acute chest pain
- admission rate
- coronary CT angiography
- emergency department
- length of stay
- stress echocardiography
This study was supported by American Heart Association Scientist Development Grant 11SDG7380006. The funder had no role in the study design, trial conduct, data collection/analysis/interpretation, manuscript preparation, or in the decision to submit the manuscript for publication. All authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received March 27, 2018.
- Accepted March 28, 2018.
- 2018 American College of Cardiology Foundation
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